Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease
Abstract
This study is designed to measure the change in patients diagnosed with Parkinson's disease (PD) before, during and after a12-week exercise program. The focus of this study is the glymphatic system. The glymphatic system is a recently discovered novel waste clearance pathway, in patients with Parkinson's Disease (PD). The glymphatic system acts as a waste-clearance system in the brain of vertebrate animals. The glymphatic system has been proposed in which new clearance pathways involving communication between paravascular spaces, interstitial fluid, and ultimately meningeal and dural lymphatic vessels exists, and we have provided evidence that this system may be dysfunctional in patients with Parkinson's disease with cognitive disorders. Early research suggests glymphatic function increases following exercise, this response is believed to clear beta amyloid in the brain and may mediate the neurobehavioral response to exercise in PD. This study will use cognitive exams, neurological exams as well as specialized imaging to record data points and evaluate the glymphatic function after exercise.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1166792
Entities
People
- Ciaran Considine
- Daniel O. Claassen
Organizations
- Vanderbilt University Medical Center