Sensitizing Ovarian Cancer to PARP Inhibition by Targeting Claudin-4 Activity

Abstract

Purpose: To define the mechanisms of claudin-4 induced PARP inhibitor resistance in ovarian cancer. Scope: The work used ovarian cancer cells, mouse models of ovarian cancer, and primary human tumors to assess claudin-4 expression and response to PARP inhibitors. The findings of the work have broad implications in not only improving understanding on ovarian cancer biology but all in cancers being treated with PARP inhibitors. Major Findings: We discovered claudin-4 is directly related to DNA damage repair, replication stress, and mitotic spindle assembly. Also, loss of claudin-4 improves sensitivity to PARP inhibitors.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1166801

Entities

People

  • Benjamin G Bitler

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Resistance
  • Statistical Tests
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

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  • Military History
  • Molecular and genetic basis of cancer.