Using Multimodal Imaging to Examine the Neural Mechanisms of an Integrative Exercise Program for Individuals with Dementia

Abstract

The goal of this project is to investigate whether participation in the Preventing Loss of Independence through Exercise (PLIE) program for 4 months will result in neurobiological changes that improve cognitive function, leading to improvements in physical function and quality of life (QOL). We will estimate the impact of PLIE on brain atrophy rates, Default Mode Network (DMN) functional connectivity, and cerebral perfusion and determine if improvements in cognition, function, and QOL are associated with changes in brain volume, DMN functional connectivity, and cerebral perfusion in individuals who participated in PLIE.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1166810

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  • Linda L Chao

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  • Northern California Institute for Research and Education

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  • Biomedical

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  • Alzheimer Disease
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  • Cognitive Impairment
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