Measuring Glial Metabolism in Repetitive Brain Trauma and Alzheimer's Disease

Abstract

The overall aim of the study is to better understand glial metabolism within the context of repetitive brain impacts and Alzheimer's disease and its potential findings in veterans. In preparation for the start of the study, we have conducted a number of studies to quantify the improvement moving from 3T to 7T. We also present data comparing military and sports-related repetitive brain trauma and show that changes in glutamate show similar patterns. These results support our initial hypothesis and illustrate the importance of measuring glial metabolism using indirect detection of 13C-labeled metabolism.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1167693

Entities

People

  • Alexander Lin

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Alzheimer Disease
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Chronic Encephalopathy
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Glutamates
  • Head Injuries
  • Health Services
  • Institutional Review Board
  • Magnetic Resonance
  • Medical Personnel
  • Metabolism
  • Neurodegeneration
  • Neuroimaging
  • Spectroscopy

Readers

  • Molecular and Cellular Biochemistry
  • Theoretical Analysis.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.