Making Tactical Practical- Pragmatic Solutions to Preventing Neurologic Effects of Early Aeromedical Evacuation (AE) in the Head Injured Patient

Abstract

Early aeromedical evacuation (AE) after traumatic brain injury (TBI) has been associated with worse neurologic outcomes. No potential therapeutics have been evaluated to prevent secondary injury induced by the hypobaric hypoxia (HHH) environment integral to post-injury AE. This study examined the role of allopurinol/propranolol/tranexamic acid (TXA)/adenosine/lidocaine/magnesium (ALM)/amitriptyline administration prior to simulated flight. Murine Propranolol lowered post-TBI HR with reduced pro-inflammatory effects, including p-tau reduction. Amitriptyline induced lower post-TBI HR and improved functional outcomes without affecting inflammatory response. Allopurinol did not affect vital signs but improved late post-TBI systemic inflammation and functional outcomes.

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Document Details

Document Type
Technical Report
Publication Date
Jan 11, 2022
Accession Number
AD1167704

Entities

People

  • Emily Mcglone
  • Jackie Youngs
  • Jennifer L. Mcguire
  • Kathleen E. Singer
  • Mackenzie C. Morris
  • Matthew R. Baucom
  • Michael D Goodman
  • Rebecca M. Schuster
  • Richard Strilka
  • Ryan Earnest
  • Sabre Stevens-topic
  • Taylor E. Wallen
  • Thomas C Blakeman

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Aeromedical Evacuation
  • Air Force
  • Air Force Research Laboratories
  • Blood
  • Blood Flow
  • Brain Injuries
  • Cardiovascular System
  • Cerebrovascular Disorders
  • Chemistry
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel
  • Patient Care
  • Proteins
  • Therapy
  • Vital Signs
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma or Military Medicine
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.