Polyethylene Glycol (PEG)-Mediated Fusion (PEG Fusion) Repair of Mixed Motor-Sensory Acute Peripheral Nerve Injuries (PNI) for Rapid and Immediate Improvement in Outcome
Abstract
Using four Primary Investigators at 3 Universities, 1 military treatment facility, and several other civilian and military clinical trial sites, the investigators will attempt to drastically improve outcomes from PNI by reconnecting severed axons to rapidly restore nerve function and prevent further downstream denervation injury such as muscle atrophy and loss of neuromuscular junctions. At the same time, preliminary cell based research into maintaining denervated muscle mass independent of axonal fusion and/or regeneration will begin. This addresses elements of BOTH focus areas of Peripheral Nerve Regeneration and Skeletal Muscle Regeneration and addresses the following areas of encouragement: Immediate reconnection of severed peripheral nerves, regenerative therapies for volumetric muscle loss, preservation of denervated end organs, Maintenance of the motor end plate or regeneration of the neuromuscular junction, and improving the rate of peripheral nerve regeneration. This effort will be coordinated across clinical trial sites and laboratories among the partnering institutions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1168738
Entities
People
- Jaimie Shores
Organizations
- Johns Hopkins University