The Role of the Gut Microbiome in Colorectal Cancer

Abstract

Inflammatory bowel disease (IBD) is a chronic condition of the gastrointestinal tract that predisposes individuals to develop CRC. Chronic inflammation is one of the key hallmarks of cancer and dysbiosis of the gut microbiome is proposed to promote CRC. The prevalence of IBD has increased 2- to 3-fold among veterans. The objective of this proposal is to utilize Il10-/- mice, a model of human IBD, together with Stat2-/- mice, which are more resistant to CRC to: 1) identify unique microbial communities in the gut and 2) metabolites of bacterial and host origin that mediate anti-inflammatory and antitumor effects to control inflammation and drastically reduce the risk of CRC development.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1168856

Entities

People

  • Ana Gamero

Organizations

  • Temple University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Body Weight
  • Breeding
  • Cancer
  • Colon Cancer
  • Communities
  • Covid-19
  • Deficiencies
  • Dysbiosis
  • Education
  • Gastrointestinal Tract
  • Genetics
  • Gut Microbiome
  • Inflammation
  • Maryland
  • Metabolites
  • Microbial Genetics
  • Microbiomes
  • Professional Development
  • Proteobacteria
  • Students
  • Training
  • Urban Areas

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech