Neurovascular Changes Associated with Olfactory Deficits in Early Parkinson's Disease

Abstract

The purpose of this study is to investigate neurovascular changes related to the olfactory deficits in early PD patients to develop novel biomarkers for PD. We plan to focus on these Specific Aims: 1) neurovascular abnormalities associated with olfactory deficits in early PD patients; 2) dynamic changes in neurovascular and metabolic parameters during olfactory stimuli in early PD patients; and 3) the progression of such neurovascular abnormalities across different stages of PD patients. We have completed all proposed recruitment and data acquisition and analysis. Scientifically, we found significant neurovascular changes (Aims 1 and 2), impaired dynamic responses to olfactory stimulation (Aims 2 and 3), and structural abnormalities (additional exploratory analysis) in primary and secondary olfactory regions in the brains of PD patients compared to controls. We have published our results in 2 journal papers and 9 conference abstracts, and are working on 2 additional journal papers.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2022
Accession Number
AD1169467

Entities

People

  • Jun Ha

Organizations

  • Kennedy Krieger Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Arteries
  • Brain
  • Brain Diseases
  • Data Acquisition
  • Data Mining
  • Data Science
  • Dementia
  • Health Services
  • Information Science
  • Medical Personnel
  • Neurodegeneration
  • Neuroimaging
  • Neurosciences
  • Parkinson'S Disease
  • Psychology

Fields of Study

  • Biology
  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neuroscience
  • Technical Research and Report Writing.