Mesoscale Nanotechnology: A Novel Therapeutic Strategy in Polycystic Kidney Disease

Abstract

Aim 1. Evaluate therapeutic efficacy of nanoparticle-targeted mTOR inhibition in a rat model of PKD Mesoscale nanoparticles will be synthesized to encapsulate an ASO against mTOR. We will use the PCK-Pkhd1pck rat model of PKD that closely mimics ADPKD in humans. Efficacy will be evaluated by longitudinal serial live imaging via MRI, as well as post-mortem phenotypic surrogate markers of renal cystogenesis. Aim 2. Evaluate therapeutic efficacy of nanoparticle-targeted miR-17 inhibition in a rat model of PKD Mesoscale nanoparticles will be synthesized to encapsulate an oligonucleotide against miR-17. Just like in Aim 1 we will use the Pkhd1pck/pck rat model of PKD that closely mimics ADPKD in humans. Efficacy will be evaluated by longitudinal serial live imaging via MRI, as well as post-mortem phenotypic surrogate markers of renal cystogenesis.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2022
Accession Number
AD1169500

Entities

People

  • Edgar A. Jaimes

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cancer
  • Cells
  • Clinical Trials
  • Covid-19
  • Detection
  • Diseases And Disorders
  • Electronic Cigarettes
  • Health Services
  • Infectious Diseases
  • Kidney Diseases
  • Medical Personnel
  • Nanotechnology
  • Neoplasms
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  • Therapy

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Medical Imaging.
  • Molecular and Cellular Biology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech