Oncobioenergetics of Breast Carcinogenesis

Abstract

Several reports from human studies and animal models of breast carcinogenesis have established that puberty is a critical window for the increased susceptibility to mammary cancer. We reasoned that field carcinogenesis or cancerization effect (FCE) could play acritical role in increasing the risk of mammary cancer at puberty. Based on our preliminary studies, we proposed cancer like mitochondrial bioenergetic tissue fields as a mechanism of mammary carcinogenesis. To establish this phenomenon, we treated the animals with NAD+ precursor, which could reverse cancer-like mitochondrial bioenergetics. If our hypothesis is true, then treatment with NAD+ precursor should prevent mammary cancer. Our results show that pre-pubertal treatment of NAD+ significantly inhibited mammary cancer development in classic breast carcinogenesis model. This suggests that cancer-like mitochondrial bioenergetics play a key role in mammary carcinogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2021
Accession Number
AD1170070

Entities

People

  • Praveen K. Vayalil

Organizations

  • University of Alabama

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Age Groups
  • Assays
  • Biomedical Research
  • Body Weight
  • Breast Cancer
  • Cancer
  • Genetic Engineering
  • Genetics
  • Glands
  • Glucose
  • Glycolysis
  • Inhibitors
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Rate Of Consumption
  • Risk
  • Standards
  • Stress Tests
  • Students
  • Tissues

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biology
  • Neurotrauma and Rehabilitation Medicine.