Gene Expression in Blood, Lung, and Heart Following Exposure of Rats to Hypobaria
Abstract
Results obtained from rodent traumatic brain injury models indicate that exposure to air-evacuation-relevant hypobaria within a few days following injury worsens neurologic outcomes and exacerbates inflammatory damage to the brain, lungs, and heart. The causes for these changes are not well understood but could involve changes in gene expression in response to moderate hypobaria and hyperoxia, which often occur during air evacuation. This study tested the hypothesis that exposure of normal healthy rats to hypobaria (4000 or 8000 ft altitude) for as short as 5 hr and as long as 10 hr results in tissue-selective changes in gene expression that could provide insight into the mechanisms responsible for these effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 10, 2022
- Accession Number
- AD1170340
Entities
People
- Gary Fiskum
Organizations
- University of Maryland School of Medicine