Anesthesia Neurotoxicity in Congenital Heart Disease

Abstract

The proposed studies will provide cellular/molecular insights into caspase-induced nonapoptotic neuronal degeneration and will establish a highly translational treatment aimed at reducing neurotoxicity due to neonatal cardiac surgery and improving neurological outcome in children with CHD. The proposed study is of broad relevance for not only for CHD but other populations who need to undergo major surgery early in life.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2022
Accession Number
AD1170627

Entities

People

  • Kazue Hashimoto-torii
  • Nobuyuki Ishibashi

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cardiovascular Surgery
  • Cell Physiological Processes
  • Cells
  • Health Services
  • Heart Diseases
  • Intellectual Disability
  • Medical Personnel
  • Neurodegeneration
  • Neuroimaging
  • Neurons
  • Neurosciences
  • Proteins
  • Stem Cells

Readers

  • Molecular and Cellular Biology
  • Neuroscience
  • Trauma or Military Medicine