Cathartocytosis: A Novel Cellular Process Essential for Metaplastic Dedifferentiation
Abstract
I have discovered that the epitope recognized by mAb Das-1 and which is aberrantly expressed in foregut metaplasia and cancer are two closely related epitopes 3'-Sulfo-LeA and 3'-Sulfo-LeC. The manuscript describing these findings has been published in PLoS ONE and is attached in the appendix. Based on this knowledge we have made significant progress in molecularly characterizing the process of cathartocytosis annotated by this antigen. Our studies have also suggested that this epitope may actually play a functional role in cathartocytosis and thus inhibiting its synthesis in high-risk metaplasia and cancer from synthesizing this antigen may have therapeutic potential for esophageal, gastric, and pancreatic cancer. I have also learned that the proteins that bind these epitopes (Galectin-3, Galectin-4, and Galectin-8 affect metaplasia by inhibiting cathartocytosis (Galectin-3 and Galectin-4) or inhibit differentiation (Galectin-8). I have used these preliminary data to obtain additional funding (K08 DK132496). Over the last year, I have published an additional 4 papers, presented a lecture about this research at the premier, international gastroenterology conference Digestive Disease Week as well as presented posters elsewhere.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1172220
Entities
People
- Jeffrey W Brown
Organizations
- Washington University in St. Louis