Efficacy of Repetitive Transcranial Magnetic Stimulation for Improvement of Memory in Older Adults with TBI

Abstract

We primarily propose to assess the efficacy of rTMS to improve memory performance and to test rs-fMRI (i.e. DMN) as a potential biomarker to capture response to treatment in older patients suffering with chronic symptoms related to previous brain injuries (depression, PTSD etc.). In addition, we will assess other established biomarkers longitudinally (e.g., hypometabolism via PETFDG, cortical oscillation via electroencephalography (EEG), Brain Derived Nerve Growth Factor (BDNF) and hippocampal volume from structural MRI) to capture patient response to treatment that may signal early dementia.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1172222

Entities

People

  • Maheen Adamson

Organizations

  • Palo Alto Veterans Institute for Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • Covid-19
  • Data Acquisition
  • Electroencephalography
  • Growth Factors
  • High Resolution
  • Maryland
  • Medical Personnel
  • Procurement
  • Professional Development
  • Students
  • Technology Transfer
  • Training
  • Urban Areas

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.