Overcoming Chemoresistance in Ovarian Cancer by Targeting a Novel Lipid Hydroperoxidase Pathway
Abstract
Chemoresistance remains a critical challenge in ovarian cancer that has stymied the achievement of cures. Dysregulation of apoptosis has been proposed as a mechanism underlying this phenomenon, and methods to re-sensitize chemoresistant ovarian cancer cells to apoptosis are being explored. In this project, we seek to explore a novel avenue that builds upon preliminary results showing therapy-resistant ovarian cancer cells to be highly susceptible to ferroptosis, a non-apoptotic form of cell death. The goals of this proposal are primarily to validate the preliminary findings in physiologically-relevant models of ovarian cancer which include patient-derived xenograft cells and fresh patient ascites-derived cells. A secondary aim is to gain initial clues into the mechanisms that may underlie ferroptosis sensitivity in these therapy-resistant ovarian cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2021
- Accession Number
- AD1172653
Entities
People
- Vasanthi Viswanathan