Nasal Oxytocin for the Treatment of Post-TBI Chronic Headache: Influence of Estrogen
Abstract
The funded project examines the impact of estrogen on the analgesic effect of nasally applied oxytocin in a rodent model of headache caused by traumatic brain injury. This report details efforts made during the first year plus of the funded project. The study began during Covid restrictions on laboratory work at Stanford, and so there were (and to some extent still are) delays secondary to the pandemic. However, we were able to achieve IACIC and ACURO protocol approval, recruit a qualified postdoctoral fellow, construct the TBI apparatus, begin demonstration of the allodynic effects of TBI and the analgesic effects of nasal oxytocin in pot-TBI rats. We were also able to begin electrophysiologic testing of trigeminal ganglia (TG) neurons from female rats a prerequisite of testing of the impact of estrogen pretreatment on the effect of oxytocin as a inhibitor of these pain-sensing neurons. Finally, we used the time during which we could not do laboratory work to publish a paper describing a theory of the pathogenesis of menstrual migraine, which posited that the decrease in estrogen during menses drives decreases in TG oxytocin receptor activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2022
- Accession Number
- AD1173409
Entities
People
- David C Yeomans
Organizations
- Stanford University