Effects of Hypobaria on Brain Injury and Mortality Following Head Trauma Combined with Hemorrhagic Shock

Abstract

Our previous Air Force-funded research demonstrated that exposure of rats to 6 hour (hr) of hypobaria (approx. 8000 ft altitude equivalent) at up to 72 hr after mild to moderate traumatic brain injury (TBI) worsens neurologic and neuropathologic outcomes compared to those in rats that do not experience hypobaria. Our more recent objective was to determine whether similar effects of hypobaria are present in animal models of polytrauma consisting of impact TBI in combination with mild hemorrhagic shock.

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Document Details

Document Type
Technical Report
Publication Date
Feb 21, 2022
Accession Number
AD1173556

Entities

People

  • Gary Fiskum

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Aeromedical Evacuation
  • Air Force
  • Air Force Research Laboratories
  • Analgesia
  • Arteries
  • Blood
  • Body Weight
  • Brain
  • Brain Injuries
  • Cells
  • Chemistry
  • Contracts
  • Endothelial Cells
  • Evacuation
  • Government Procurement
  • Governments
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Information Exchange
  • Lung Diseases
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Maryland
  • Medical Personnel
  • Military Medicine
  • Motor Skills
  • Wounds And Injuries

Fields of Study

  • Medicine
  • Psychology

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Trauma or Military Medicine
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.