Characterizing the Antimicrobial Effectiveness of Novel Nano-Zeolite Metal Formulations Against Multiple Pathogenic Bacterial Species In-vitro
Abstract
The U.S Military requires improved sterility and disinfection strategies in austere medical settings. Inorganic transition metal ion disinfectants bind to various bacterial constituents to affect viability. Unfortunately, there activity of metal ions reduces their efficiency as a disinfectant in real-world applications. Zeolites are crystalline high internal surface area microporous aluminosilicates formed by interlocked TO4 tetrahedra (T-Si, Al), which show widespread applications in many industrial processes such as catalysis, adsorption, and separation. Zeolites can also store transition metal ions in their supercage cavities through electrostatic interactions and ion exchange. A novel compound nanozeolite (NZ), 30nm Faujasitic zeolite crystals, has been developed and is commercially available and may be able to serve as a reservoir of metal ions, directly delivering them to microbial targets. We hypothesized that NZ impregnated with metal will have an increased antimicrobial effect in a shorter duration due to the effective zeolite-bacteria surface interactions, faster ion-release kinetics, and bacterial penetration. This project utilizes EPA-recognized disinfectant testing strains, Pseudomonas aeruginosa (ATCC15442 and Staphylococcus aureus (ATCC6538) to test the antimicrobial efficacy of NZ formulations encapsulated with Ag^+, Zn^2+, and Cu^2+.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 2022
- Accession Number
- AD1174259
Entities
People
- A M Nagy
- M A Cristner
- P. K. Dutta
- S Norouzi
- S. A. Hill
- Sujan Shrestha
Organizations
- 59th Medical Wing