Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties

Abstract

Patients who initially survive from traumatic thoracic injury are at risk for Acute Respiratory Distress Syndrome (ARDS). The only proven treatments available once ARDS has developed are low tidal volume ventilation (ARDSnet) and proning, but there is no existing treatment strategy to prevent the onset of ARDS following traumatic injury. As a potential solution, recent evidence suggest that prothrombin complex concentrate (Kcentra) acts similarly to plasma to prevent vascular leak and edema, but this has not been investigated in the trauma setting. Therefore, the purpose of this project is to conduct a series of in vitro and in vivo studies to determine if the therapeutic administration of Kcentra prevents the development of ARDS following pulmonary contusion and hemorrhagic shock.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1175577

Entities

People

  • Martin A. Schreiber

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Arteries
  • Biomedical Research
  • Blood
  • Department Of Defense
  • Gene Expression
  • Health Services
  • Hemorrhagic Shock
  • Lung Diseases
  • Medical Personnel
  • Thoracic Injuries
  • Universities
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Fire Suppression Systems Design.
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology