Transferrable Active Chemical Structures for Bottom-Up Heterogeneous Tissue Engineering
Abstract
Cell-cell interactions drive the organization of complex tissues. Studying these interactions has generally involved the use of either in vivo models or single-purpose microfluidic devices which cannot be reconfigured when experimental needs change. Here we show that graphene-based materials can be used as the basis for transferrable active chemical structures. We also demonstrate how these structures can be integrated biocompatibly with living tissue. In addition, we demonstrate passive structures that can be used to mask cells from various biochemical stimuli in a spatially pre-determined manner, and we extend the use of these passive structures to create multi-cell-type co-cultures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 08, 2022
- Accession Number
- AD1176542
Entities
People
- Christopher R. So
- Cy R. Tamanaha
- Dhanya Haridas
- James M Roberts
- Keith E Jr Whitener
- Matthew D Thum
- Saron P. Yoseph
- Woo-Kyung Lee
- Xavier Langston
Organizations
- United States Naval Research Laboratory