The Pathogenesis of Post Traumatic Pulmonary Embolism: A Prospective Multi-center Investigation by the CLOTT Study Group
Abstract
Venous thromboembolism, which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially mortal complication after injury in both civilian and military settings. To date, there are no methods that have been definitively demonstrated to prevent post-traumatic pulmonary embolism (PE) which carries a mortality of 11 percent and is the third leading cause of death following injury. PE is particularly common among combat casualties due to the prevalence of certain risk factors such as multiple amputations, traumatic brain injury, the need for transfusions, and prolonged immobilization during evacuation. All sites completed enrollment of participants except when restricted due to COVID-19 in CLOTT Part 1 and Part 2. Due to COVID-19, CLOTT Part 2 sites required additional time to meet enrollment targets. A 12-month extension without funds was approved. In Year 4, all CLOTT sites (17) initiated notices to their local IRBs that the federal funding was ending so that protocols can be closed with HRPO (underway). Sites completed data collection and cleaning. The first paper on CLOTT Part 1 was published in December 2021. Part 2 findings were be presented and submitted for publication in Spring 2022.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2022
- Accession Number
- AD1177761
Entities
People
- Mary Margaret Knudson
- Michelle A. Price
Organizations
- National Trauma Institute