Expanded Development and Application of an Array-Based Mathematical Model for Fuels Exposure and Dosimetry
Abstract
An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined way to quantify dosimetry of multiple compounds resulting from exposure to a mixture. In order to predict internal dosimetry of multiple volatile components of jet fuel simultaneously, an array PBPK model was previously coded to simulate inhalation exposures. The volatile components included decane, nonane, toluene, ethyl benzene, and xylene. In the current effort, naphthalene was added to the array and validated against available data from the literature. The model structure accounts for metabolism of the compounds in the lung and liver, as well as absorption, distribution, metabolism and elimination of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling. The model satisfactorily simulates circulating blood levels and tissue dosimetry of each of the compounds resulting from a rat inhalation study. The model was utilized to predict differences in tissue kinetics for a published study. The model also was used to provide kinetic comparisons between JP-8 and a Virent Synthesized Aromatic Kerosene (SAK):JP-8 50:50 blend.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 05, 2022
- Accession Number
- AD1178086
Entities
People
- David R. Mattie
- Elaine A. Merrill
- Gunda Reddy
- Peter J. Robinson
- Teresa R Sterner
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine