Revisions to Physiologically-Based Pharmacokinetic Modeling in the Development of Health Protective Levels for Trichloroethylene
Abstract
Trichloroethylene (TCE) was commonly used as a solvent by the Department of Defense (DoD), as well as at private sector facilities. Releases to the environment from its past use make TCE one of the most common contaminants encountered at hazardous waste sites. In a joint effort through the TriService Toxicology Consortium, the Air Force Research Laboratory (AFRL) participated in the development of DoD health protective levels for TCE. Based on a National Academies of Sciences, Engineering, and Medicine (NASEM) review of the occupational exposure limit (OEL) development, the prior work was revised. This report identifies revisions related to the physiologically-based pharmacokinetic modeling portion of the OEL development. Details for dose metric predictions and human equivalent concentration estimates for which the points of departure did not change based on NASEM recommendations are also included here for completeness. Much of this text is the same as in Covington et al. (2019) with additions and modifications made as necessary to reflect the revisions as a result of comments and suggestions from the NASEM review.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2022
- Accession Number
- AD1178089
Entities
People
- Jeffery M. Gearhart
- Tammie R. Covington
- Teresa R Sterner
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine