Central Lateral Thalamic Circuitry Abnormalities in Traumatic Brain Injury and Alzheimer's Disease
Abstract
The purpose of this grant is to understand how the circuitry associated with the central lateral thalamic nucleus (CL) plays a role in enhancing the risk for Alzheimer's disease (AD) following a traumatic brain injury (TBI). Animal connectivity work shows that CL has strong connections with the dorsal anterior cingulate cortex (dACC), which is heavily involved in both attention and memory. We hypothesize that the downregulation of CL in TBI leads to decreased activity in the dACC, which in turn downregulates the memory system and enhances the risk for AD. This will be tested by quantifying the connectivity strength between CL and dACC in resting-state fMRI and DTI neuroimaging data from healthy versus TBI versus AD subjects from the ADNI and DoD-ADNI databases. We will then examine whether the CL-dACC connectivity strength inversely correlates with markers of AD (performance on the Logical Memory II test, global PET-amyloid burden, and amyloid and tau levels in the cerebrospinal fluid). Thus far, per the Statement of Work for Year 1, Major Task 1 Subtask 1 has been completed: data have been downloaded from the ADNI and DoD-ADNI databases. Major Task 1 Subtask 2 is partially complete. Subject specific PHC and dACC ROIs have been defined for all subjects. Work is in progress for defining subject-specific CLROIs. Progress has been slowed because of a delay in hiring a Data Analyst to assist with tasks. We expect that the remainder of Year 1 tasks will be accomplished within three months in Year 2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1178550
Entities
People
- Eun Young Choi
Organizations
- Stanford University