Mismatch Repair Loss Renders ER+/HER2- Breast Cancer Susceptible to HER2/3 Inhibition

Abstract

The objective of this proposed study is to investigate a role for HER2/3 activation in MutLdefective ER+ breast cancer progression and resistance to endocrine therapy. By targeting HER2/3 signaling and key nodes of adaptive kinome response, we aim to significantly improve patient disease-specific survival.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1178562

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  • Svasti Haricharan

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  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).