Mechanisms of Epileptogenesis and Circuit Dysfunction in a Mouse Model of TSC
Abstract
Epilepsy in Tuberous Sclerosis Complex (TSC) is often resistant to traditional anti-epileptic drugs and to mTOR inhibitors. The structure and function of a brain circuit early after the onset of epilepsy may be different from that late in the course of epilepsy when seizures are drug resistant. Structure and function rely on gene expression. If we can compare gene expression of neurons at these early and late time points after the development of epilepsy, including when seizures are drug-resistant, we may be able to identify important genes and proteins involved in drug-resistant seizures. This knowledge may not only reveal underlying mechanisms of drug-resistance but may guide the development of more effective treatments. We are using a mouse model which exhibits the same seizure and drug resistance as TSC patients. In this first year of study, we found that mTOR pathway is reactivated which parallels the return of epileptic seizure and despite the continuous presence of the mTOR inhibitor RAD001.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1178591
Entities
People
- Anne Anderson
Organizations
- Baylor College of Medicine