NF1-Associated Peripheral Nerve Sheath Tumors at Single-Cell Resolution: Heterogeneity, Tumor Growth, and Malignant Progression

Abstract

We hypothesize that some of the pNF cell populations expressing SCP markers could act as a pNF stem-like cell. We think these cells mighthave an important impact on pNF growth, progression to malignancy and response to treatment. In addition, we hypothesize that pNF FBsprovide trophic and niche conditions essential to maintain this pNF stem-like cell population. Finally, a fine characterization of expression andmutation status at single cell level may uncover the cells undergoing tumor progression. These cells need to be present in faithful models tohelp characterize the impact of drug treatments on different tumor cell subpopulations.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2022
Accession Number
AD1178593

Entities

People

  • Bernat Gel
  • Eduard Serra
  • Meritxell Carrio

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cells
  • Cellular Structures
  • Data Analysis
  • Data Sets
  • Dimensionality Reduction
  • Embryos
  • Gene Expression
  • Heterogeneity
  • Identification
  • Neoplasms
  • Nerves
  • Nervous System
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Ribonucleic Acids
  • Separators
  • Spatial Distribution
  • Standards
  • Transcriptomics

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.