Discovery and Characterization of Functional Breast Cancer Microproteins

Abstract

There were two significant findings during the research period. First, in collaboration with Dr. Adolfo Ferrando we found that TINCR is a tumor suppressor in squamous cell carcinoma. Second, we completed our CRISPR/Cas9 screen and identified nearly 1000 smORFs that regulate breast cancer growth. An amazing finding that we will validate and further characterize.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1179172

Entities

People

  • Alan Saghatelian

Organizations

  • Salk Institute for Biological Studies

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Coding
  • Culture Techniques
  • Diseases And Disorders
  • Epithelial Cells
  • Genes
  • Genetic Code
  • Genetics
  • Human Genome
  • Medical Personnel
  • Metabolic Diseases
  • Neoplasms
  • Proteins
  • Skin Cancer
  • Suppressors

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology