The Effects of Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) with Pharmacologic Treatment in Swine Models of Hemorrhagic Shock, Traumatic Brain Injury, and Complex Vascular
Abstract
The goal of this project is to provide practical solutions for the control of non-compressible torso hemorrhage. We plan to achieve this objective by combining two innovative strategies to make REBOA more practical for the military and austere use, and by testing these approaches in clinically realistic large animal models. Specific Aim 1: Determine the effects of c-and pREBOA, with and without VPA, on brain lesion size and edema, spinal cord injury, damage to organs distal to the aortic occlusion (e.g. kidney, liver, bowel, muscles), and global ischemia reperfusion injury in swine models of combined controlled hemorrhagic shock (HS) and severe traumatic brain injury (TBI).Specific Aim 2: Study the consequences of c- and pREBOA, with and without VPA treatment, on hemorrhage control, long term survival, neurological outcomes, and multiple organ injury, in swine models of combined uncontrolled HS and TBI. Specific Aim 3: Elucidate the underlying physiological and cellular mechanisms that are altered by the application of REBOA (cREBOA and pREBOA), as well as the administration of VPA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 24, 2021
- Accession Number
- AD1179800
Entities
People
- Glenn Wakem
- Hasan B Alam
- Jessie Ho
- Michael G Kemp
- Rachel Russo
- Toby Keeney-bonthrone
- Yongqing Li
Organizations
- Northwestern University