A Feasibility Protocol to Examine the Use of Genetic Biomarkers for Noise-Induced Hearing Loss in a Sample of Military Personnel

Abstract

Noise-induced hearing loss (NIHL) and age-related hearing impairment are two of the most common conditions demonstrating sensory injury to the auditory nerve, specifically cochlear hair cells damaged in hearing loss (Clifford et al., 2019). NIHL can result from a single exposure to an intense sound (e.g., explosion) or from continuous exposure to noise over a long period of time (e.g., occupational exposure to loud machines). Precision medicine can use genetic biomarkers as indicators of normal biological processes, disease states, and pharmacological responses to therapeutics. Being able to anticipate who might be more susceptible to NIHL using genetic markers could improve military readiness and performance, and reduce service-related disability.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1180412

Entities

People

  • Carlos Esquivel
  • Carson Rutter
  • Duane Robinson
  • Erin Cesario
  • Julieta Scalo
  • Kathryn Marshall
  • Nicole Larionova
  • Suheily Lovelace
  • Thomas Gibbons
  • Victoria Tepe

Organizations

  • United States Department of Defense

Tags

DTIC Thesaurus Topics

  • Air Force
  • Chemical Synthesis
  • Chemistry
  • Deoxyribonucleic Acids
  • Department Of Defense
  • Ear
  • Education
  • Genetic Markers
  • Governments
  • Health Services
  • Hearing Disorders
  • Hearing Loss
  • Institutional Review Board
  • Medical Personnel
  • Military Medicine
  • Military Operations
  • Military Personnel
  • United States Government

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology