Estimation of Inflammation and Repair Parameters for a Superficial Thermal Burn Model

Abstract

Ionizing radiation delays the wound healing process in thermal burns. A model describing the local inflammatory response and early fibroblast activity triggered by a locally irradiated superficial thermal burn is presented. Its features include diminished immune cell infiltration; polarization towards a macrophage phenotype; and fibroblast dysfunction. Numerical simulations show the model's ability to capture the dose-effect relationship between healing time and radiation dose as well as other known biological dynamics.

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Document Details

Document Type
Technical Report
Publication Date
Sep 22, 2022
Accession Number
AD1180646

Entities

People

  • Amy Creel
  • Angela Reynolds
  • Rachel Jennings

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acceptability
  • Burns
  • Calibration
  • Cardiovascular System
  • Cells
  • Computational Biology
  • Differential Equations
  • Lymphocytes
  • Measurement
  • Medical Personnel
  • Military Personnel
  • Phagocytes
  • Radiation
  • Sampling
  • Statistical Sampling
  • Steady State
  • Systems Biology
  • T Lymphocytes
  • Thermal Burns
  • Thermal Radiation
  • Wound Healing

Fields of Study

  • Physics

Readers

  • Nuclear and Radiation Engineering.
  • Oncology
  • Trauma or Military Medicine