Studies on the Fusion and Attachment Envelope Glycoproteins of Mojiang Henipavirus: Function, Structure and Serologic Applications in Rodents
Abstract
Mojiang virus (MojV) is a recently discovered paramyxovirus of the genus henipavirus, which includes highly pathogenic zoonotic species. Henipaviruses employ the concerted action of their fusion (F) and attachment (G) glycoproteins to mediate host cell entry by utilizing ephrin ligands as entry receptors. While the natural reservoirs for all henipaviruses have been pteropid bats, MojV was the first henipavirus identified in rodent specimens, which raises important questions about its receptor tropism and host range.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 28, 2020
- Accession Number
- AD1182677
Entities
People
- Sofia C Da Silva
Organizations
- Uniformed Services University of the Health Sciences