Characterization of the Interactions of Pregnancy-Specific Glycoprotein 1 (PSG1) with Extravillous Trophoblasts and Endothelial Cells

Abstract

Pregnancy-specific glycoproteins are secreted predominantly by the syncytiotrophoblast of the placenta. Humans have ten protein-coding PSG genes (PSG1-PSG9, and PSG11), and PSG1 is the most highly expressed throughout pregnancy. PSG1has been previously reported to have immunomodulatory and pro-angiogenic functions. While the immunoregulatory role of PSG1 has been extensively studied, a potential role of this protein in the processes of placenta development has not been investigated. Our laboratory has previously determined that PSG1 binds to extravillous trophoblasts(EVTs) and endothelial cells (ECs) and we hypothesized that PSG1 could contribute to placental invasion and angiogenesis through the interaction with these cells

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Document Details

Document Type
Technical Report
Publication Date
Jan 21, 2020
Accession Number
AD1182830

Entities

People

  • Shemona Rattila

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Embryos
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Polymeric Films
  • Pregnancy Complications
  • Proteins
  • Proteomics
  • Surface Plasmon Resonance

Fields of Study

  • Biology

Readers

  • Aerodynamics.
  • Immunology
  • Molecular and Cellular Biology