Identifying Molecular Driver Events in Salivary Acinic Cell Carcinomas

Abstract

Salivary acinic cell carcinoma (AcCC) is typically a low-grade adenocarcinoma found most commonly in the parotid gland. These tumors can undergo high grade transformation(HGT) and loco-regional recurrence and metastases. Histopathology of this tumor is characterized by acinar differentiation. This histopathology suggests conserved genetic driver events which immortalize cells. Recently NR4A3 has been reported as an oncogenic transcription factor in AcCC.

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Document Details

Document Type
Technical Report
Publication Date
Jun 24, 2020
Accession Number
AD1182844

Entities

People

  • Matthew E Seedall

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Acinar Cells
  • Biological Staining And Labeling
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Demographic Cohorts
  • Histopathology
  • Immunohistochemistry
  • Immunostaining
  • Literature Surveys
  • Lymphatic System
  • Materials
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Parotid Glands
  • Pathology
  • Salivary Glands
  • Stem Cells
  • Tissues
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Nuclear Non-Proliferation and International Security
  • Oncology

Technology Areas

  • Biotechnology