Functional Changes in Mouse Behavior Following Three Different Models of Traumatic Brain Injury
Abstract
Mild traumatic brain injury (mTBI) remains a challenge for military and veteran health systems as well as global health. Pre-clinical models that better represent the mechanism of different types of mTBI are needed for elucidating the physiological consequences of injury and their behavioral outcomes. Thus, three closed-head mTBI mouse models were utilized to assess the effects of common types of mTBI seen inservice members: blast-induced traumatic brain injury (BTBI), single concussive brain injury (CBI), and frontal repetitive CBI (frCBI). After BTBI and CBI, mice showed transient hypoactivity in home-cage activities 24 hours post-injury (PI), which returned to baseline by 48 to 72 hours PI. BTBI mice demonstrated hypoactivity in the open field(OF) and decreased anxiety at 24 hours PI. CBI mice, in contrast, demonstrated decreased anxiety at 24 and 72 hours PI in the OF. frCBI resulted in decreased freezing behavior in response to the fear conditioning context and cue. Sex differences were noted with male mice showing less freezing behavior than female mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 24, 2020
- Accession Number
- AD1182872
Entities
People
- Patricia Anh Thu Vu
Organizations
- Uniformed Services University of the Health Sciences