Volumetric Changes in Edentulous Alveolar Ridges Following Augmentation with Reinforced Polytetrafluoroethylene Mesh
Abstract
Introduction: The four foundational tenets of guided bone regeneration (GBR) include primary closure, angiogenesis, space maintenance and blood clot stability. Technological advancements in membrane design for GBR applications have improved rigidity for improved space maintenance through titanium reinforcement. Manufacturers have also focused their design efforts on enhancement of biocompatibility and fluid diffusion in order to promote predictable primary wound closure. Fluid diffusion plays a key role in providing nutrient flow from the graft and underlying bone to the gingival flap that covers the membrane-graft complex. Historical approaches to GBR have employed many types of membranes, including resorbable membranes and non-resorbable membranes with either a total absence of pores, the presence of micropores, or a macropore design. The ultimate goal of a membrane is to promote optimal hard tissue regeneration through adequate nutrient diffusion, while maintaining space and excluding soft tissue ingrowth. Objectives: This study will quantify volumetric changes in hard and soft tissues on edentulous ridges following GBR using a non-resorbable, titanium-reinforced polytetrafluoroethylene mesh designed with 0.66mm macropores. Methods: Fourteen subjects requiring GBR prior to dental implant placement will be enrolled. Bone augmentation surgery will be performed using a standardized approach. Volumetric change will be assessed using 3D reconstruction of the edentulous area. Baseline CBCT imaging will be compared to follow-up CBCT imaging captured 6 months after surgery to evaluate hard tissues. Baseline intraoral scans will be compared to 2-4 week and 4 months scans following dental implant placement to evaluate soft tissue change. Results: This long-term clinical study is pending approval by the WRNMMC Institutional Review Board.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2021
- Accession Number
- AD1183064
Entities
People
- Stefano A. Palazzolo
Organizations
- Uniformed Services University of the Health Sciences