Characterization of Persistence and a Novel Cytoskeletal Protein in Chlamydia Trachomatis
Abstract
The regulation of cell division is critically important for intracellular pathogens. Chlamydia trachomatis, an obligate intracellular bacterium, must replicate rapidly in order to sustain an active infection. Paradoxically, the pathogen must release its infectious forms only when conditions are suitable for their extracellular survival. It has been previously demonstrated that C. trachomatis must first decrease in size in order to transition to their infectious forms. However, C. trachomatis does not utilize a peptidoglycan-containing cell wall and lacks many of the canonical genes associated with regulating bacterial cell size and division. Our overall goal was to investigate how C. trachomatis initiates cell division and how halting cell division affects the interactions between the pathogen and its host.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 2021
- Accession Number
- AD1186110
Entities
People
- Mary R. Brockett
Organizations
- Uniformed Services University of the Health Sciences