Neuroinflammation and Sensorimotor Dysfunction in a Mouse Model of Mild Cortical Contusion Traumatic Brain Injury and the Therapeutic Potential of Human induced Pluripotent Stem Cell-Derived Neural Cell Transplantation
Abstract
Traumatic brain injury (TBI) remains a significant health and economic burden as a major contributor to death and disability. The failure to generate effective therapies is often attributed to the heterogeneous nature of injury mechanisms and outcomes which challenge preclinical modeling. In addition to injury severity and pre-existing vulnerabilities to brain damage, biologic sex represents a significant yet complex variable in TBI pathogenesis. Acute trauma to the brain initiates a cascade of metabolic and biochemical changes directed by neuroinflammatory processes that can prolong injury, hinder restoration, and lead to chronic neurodegeneration. Stem cell (SC)-based therapies are a promising approach to address neuroinflammation following brain injury and promote neuro-restorative processes, yet treatment strategies remain to be optimized for clinical use.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 26, 2021
- Accession Number
- AD1186120
Entities
People
- Michael D. Nieves
Organizations
- Uniformed Services University of the Health Sciences