Phase Separation of FUS: A Potential Therapeutic Target in Cancer and Neurodegeneration
Abstract
Myxoid liposarcoma is caused by a chromosomal translocation resulting in a fusion protein comprised of the N-terminus of FUS (fused in sarcoma) and the full-length transcription factor CHOP (CCAAT/Enhancer Binding Protein Homologous Protein).FUS functions in RNA metabolism and CHOP is a stress-induced transcription factor. The FUS-CHOP fusion protein causes unique gene expression and oncogenic transformation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 2021
- Accession Number
- AD1186122
Entities
People
- Izzy Owen
Organizations
- Uniformed Services University of the Health Sciences