Card19 is a Regulator of MICOS Complex Proteins and Protects Against Mitochondrial Dysfunction in Macrophages

Abstract

CARD19 is a protein of unknown function that was first reported in 2003 to interact with BCL10 and inhibit NF-B in Jurkat T cells (196). Later investigation indicated the cDNA employed in the initial study represented an incompletely spliced mRNA product (30; 138). The fully spliced mRNA encoded a protein which localized to the mitochondria and endoplasmic reticulum in HeLa cells (30). Gene expression databases report that CARD19 is highly transcribed in both human and murine myeloidcells (46; 161; 176).

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Document Details

Document Type
Technical Report
Publication Date
Mar 12, 2021
Accession Number
AD1186131

Entities

People

  • Kariana Rios

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Body Fluids
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Liver Diseases
  • Lymphatic System
  • Lymphocytes
  • Mass Spectrometry
  • Metabolism
  • Neurodegeneration
  • Parkinson'S Disease
  • Polymeric Films
  • Proteins
  • Proteomics

Fields of Study

  • Biology

Readers

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  • Molecular Genetics
  • Molecular and Cellular Biology