Exosomes as Couriers of Inflammatory Mediators Following Acute Traumatic Injury

Abstract

Complex polytraumatic injuries induce a robust innate immune response that can lead to systemic inflammatory complications and end organ damage. Early identification of at-risk patients is essential for appropriate management and intervention. This research was aimed at exploring proinflammatory signaling in models of acute traumatic injury by investigating the kinetics of secretion and biodistribution-compartmentalization of proinflammatory mediators found associated with serum exosomes versus freely circulating forms.

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Document Details

Document Type
Technical Report
Publication Date
Nov 17, 2021
Accession Number
AD1186136

Entities

People

  • Sarah A. Walsh

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain Injuries
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Combat Casualty Care
  • Combat Injuries
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Lymphocytes
  • Medical Personnel
  • Multiple Organ Failure
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology and Biomarker-Based Cancer Detection.