SATB2 Expression in Mesenchymal and Mixed Odontogenic Tumors
Abstract
Odontogenic lesions are those originating from the tissues of the developing dentition and surrounding tissue, excluding osteogenic lesions. Often, these lesions histologically mimic other entities, sometimes even malignancies. While immunohistochemical markers are often utilized to tease overlapping lesions apart, a reliable odontogenic mesenchyme marker has not been identified at this time. SATB2, an osteogenic marker proven to be involved in odontogenesis, has been identified as a potential marker for odontogenic mesenchymal and mixed neoplasms. SATB2 immunoreactivity was assessed among odontogenic myxomas, central odontogenic fibromas, peripheral odontogenic fibromas, and ameloblastic fibromas/ameloblastic fibro-odontomas, and was scored using an H test(range 0-300). Staining with an H score greater than or equal to 100 was deemed strongly positive, and a lesion group was considered strongly positive if greater than or equal to 80 percent of the included specimens showed strongly positive H scores. Limited preliminary data demonstrated strongly reactive SATB2 staining (greater than or equal to 80 percent) among the odontogenic mesenchymal lesions, with reduced (less than 80 percent) but clinically relevant - staining observed within the peripheral odontogenic fibromas. Thus, SATB2 appears to be a useful marker for the identification and diagnosis of odontogenic mesenchymal and mixed neoplasms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2022
- Accession Number
- AD1186244
Entities
People
- Lindsay J. Jayne
Organizations
- Uniformed Services University of the Health Sciences