Intranasal Treatment with Neuroprotective Peptides Prevented Memory Performance Degradation in Sprague-Dawley Rats Subjected to Repeated Hypoxic or Hyperoxic Stress
Abstract
In this study, we report successful protection of cognitive function using neuroprotective peptides. Male, Sprague-Dawley rats were prophylactically treated with ADNP8, Semax, or Ang1-7 daily for four weeks by intranasal administration. In the fourth week, they were exposed to normobaric hypoxia (7.5 O2), hyperoxia (95 O2), or oscillating hypoxia hyperoxia (cycling between 95 and 5 O2) daily for five days. Episodic memory performance of control and treated rats were assessed using the novel object recognition test. All three peptides provided some level of protection. Semax was effective under all three exposure conditions, while ADNP-8 showed some protection in hypoxia and oscillating hypoxia hyperoxia. Ang1-7 appeared to be effective with hypoxia. These results suggest that nasal administration of neuroprotective peptides might be a useful prophylaxis against cognitive degradation induced by abnormally low and high levels of oxygen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 02, 2022
- Accession Number
- AD1186742
Entities
People
- Amanda Short
- Amber Braddock
- Chelsey Webb
- Curtis Schimmel
- David H Ellis
- Eric Perez
- Erin Roberts
- Joshua Bevins
- Judy Triplett
- Katherine Ingram
- Victor Chan
- Victoria Hutzley
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine