Reproductive and Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS) in Peromyscus spp.
Abstract
Per- and polyfluoroalkyl substances (PFAS) are compounds manufactured for use in multiple products to include paints, cleaning agents, fire suppressants, nonstick cookware, food containers, and water-impermeable products in general. PFAS are also key ingredients in highly efficient fire suppressant agents known as aqueous film forming foams (AFFFs), which have been used by the Department of Defense (DOD) since approximately 1970 for fire training and emergency response activities. Concerns about PFAS stem from their ubiquitous presence in the environment, bioaccumulation, resistance to degradation, and toxicity. In this study, PFAS were administered orally to white-footed mice (Peromyscus leucopus) or deer mice (Peromyscus maniculatus) for28 consecutive days. Then, 1:1 mating pairs were initiated and reproduction and development were evaluated. With three chemicals (perfluorononanoic acid (PFNA), 6:2 fluorotelomersulfonate (FTS), and tridecafluorohexane-1-sulfonic acid potassium salt (PFHxS)), immune response was evaluated. Data were used to derive Points of Departure (PODs) for Peromyscusvia Benchmark dose (BMD) modeling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2021
- Accession Number
- AD1187015
Entities
People
- Allison M. Narizzano
- Andrew G. East
- Meredith E Bohannon
- Michael J. Jr Quinn
Organizations
- United States Army Public Health Command