A Time-Dependent Physiological Model of Healing Initiated by an Irradiated Superficial Thermal Burn

Abstract

Ionizing radiation delays the wound healing process in thermal burns. A model describing the local inflammatory response and early fibroblast activity triggered by a locally irradiated superficial thermal burn is presented. Its features include diminished immune cell infiltration; polarization towards a macrophage phenotype; and fibroblast dysfunction. Numerical simulations show the model's ability to capture the dose-effect relationship between healing time and radiation dose as well as other known biological dynamics.

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Document Details

Document Type
Technical Report
Publication Date
Nov 09, 2022
Accession Number
AD1187081

Entities

People

  • Amy Creel
  • Angela Reynolds
  • Quintessa Hay
  • Rachel Jennings

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Bone And Bones
  • Burns
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Connective Tissue
  • Hematopoietic System
  • Hemorrhage
  • Injury Prevention
  • Ionizing Radiation
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Radiation Injuries
  • T Lymphocytes
  • Wound Infections

Fields of Study

  • Medicine
  • Physics

Readers

  • Immunology and Pathology
  • Nuclear and Radiation Engineering.
  • Trauma Surgery or Emergency Medicine.