Nano-and Bio-Electronics: Semiconductor-Enabled Exploration of Bioelectric Properties of Organelles
Abstract
Intracellular signaling is the basis of the biological activity and cellular processes. Traditionally, our knowledge about intracellular dynamics has been limited to biochemical and transcriptional pathways. However,studies over the last several decades have demonstrated that single cells also use electrical and mechanical signals for processing intracellular information. These signals can be manifested as rapid voltage changes across intracellular membranes or as localized force generation within cytoskeleton network. Additionally, the intracellular electrical and mechanical properties and dynamics tend to be rather inhomogeneous. For instance, action potentials in nerve cells are typically initiated at the axon hillock and the resultant voltage pulse travels down the myelinated axon to the nerve terminal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 23, 2021
- Accession Number
- AD1187342
Entities
People
- Bozhi Tian
Organizations
- University of Chicago