A Nanotechnology Solution for Early Detection of Micrometastatic Prostate Cancer After Radical Prostatectomy

Abstract

The overall objective of this research proposal is to conduct the initial development of a rapid circulating tumor cell-based blood test that can identify men with micro metastatic disease in order to facilitate patient selection for salvage radiotherapy. Aim 1 of this study was do perform a technical validation study and Aim 2 to embark upon testing of banked clinical specimens then to test the new assay in the setting of the NRG-GU-006 clinical trial (salvage radiotherapy +/- apalutamide). In the first year of work we have begun a series of key technical validation studies while completing the sample collection from the now fully accrued NRG-GU-006 trial. Due to COVID-19 there were delays in progress but due to rapid clinical accrual and regearing of our studies, this effort is still on time.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1189854

Entities

People

  • Edwin M Posadas

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Calibration
  • Cancer
  • Cell Line
  • Clinical Trials
  • Data Analysis
  • Detection
  • Diseases
  • Gene Expression
  • Health Services
  • Medical Personnel
  • Nanotechnology
  • Neoplasms
  • Oncology
  • Prostate
  • Prostate Cancer
  • Therapy
  • Validation

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology