Novel Dynamic Proteomics Approaches to Investigate the Systems Level Pathology of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
Abstract
ME/CFS is a severely debilitating condition characterised by unexplained, persistent and relapsing chronic fatigue of unknown pathology, typically lasting in excess of 6 months, which is significantly exacerbated by bouts of exertion/exercise. Despite its widespread nature (effecting is similar to 1-2 percent of the worlds population), little is still known regarding the underlying pathology driving these debilitating symptoms. The overall aim of this project is to use a novel dynamic proteomics approach to provide a real time measure of changes in metabolism across multiple tissues; blood, skeletal muscle and CSF, of ME/CFS patients at rest and following an acute exercise stressor designed to elicit symptoms. This will provide potential new therapeutic targets for translational to the clinical setting in the near future. This report provides an update of progress to date, highlighting the issues with volunteering particularly. We are currently struggling to recruit to the healthy volunteer group, however have had more interest within the ME/CFS group, with 4-5 potential volunteers due to be screened in the next few months hopefully.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1190388
Entities
People
- Daniel J Wilkinson
Organizations
- University of Nottingham