Molecular Targets in Endovascular Progenitors to Inhibit Lung and Skin Fibrosis in Scleroderma

Abstract

Scleroderma and pulmonary fibrosis result from the development of fibrosis of undeterminedorigin. This proposal examines the vascular endothelium as a potential source of sclerodermafibrosis through a process called endothelial to mesenchymal transition (EndMT). It aimed toexplore EndMT as a potential mechanism of fibrosis in models of skin and pulmonary fibrosisreplicating scleroderma. It also tried to explore Sox9 as a potential target for therapy as it has beendescribed as a driver of EndMT in wound healing.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2022
Accession Number
AD1190400

Entities

People

  • Kiarash Khosrotehrani

Organizations

  • University of Queensland

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Australia
  • Biomedical Research
  • Blood Vessels
  • Cancer
  • Cells
  • Department Of Defense
  • Diseases
  • Electronic Mail
  • Endothelial Cells
  • Fibrosis
  • Governments
  • Local Governments
  • Lung Diseases
  • Management Personnel
  • Medical Personnel
  • Neoplasms
  • Professional Development
  • Skin Cancer
  • Stem Cells
  • Students
  • Training
  • Transplants
  • Universities

Readers

  • Immunology and Pathology
  • Systems Analysis and Design