Interrogation of Requisite Niche Factors for Leukemia Cell Survival at Single-Cell Resolution
Abstract
The goal of this project is to identify the signals within the bone marrow microenvironment that allow acute myeloid leukemia (AML) cells to survive and proliferate. By identifying these signals, we can improve cell culture systems for maintaining AML cells outside of the body to study their true biology. We can also identify specific signals that are uniquely required by AML cells inside the bone marrow microenvironment but are not needed by healthy cells in the rest of the body and target these signals for AML-specific treatment with potentially minimal effect on normal, healthy cells. We study this question primarily in a well-known mouse model of AML, with confirmation of our mouse model findings in human AML biopsy samples.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190408
Entities
People
- Hojun Li
Organizations
- Massachusetts Institute of Technology